JOURNAL 2461


Records of Natural Products
VOLUME & ISSUE
Available Online: July 28,2022
PAGES
p.1 - 9
DOI ADDRESS
http://doi.org/10.25135/rnp.345.2205.2461
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 149 times.
AUTHORS
  • Xiaoyan Xie
  • Qingqing Zhou
  • Yanting Zhou
  • Jinbiao Xu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A pair of unique diastereoisomers of norlignan glycosides named cephalotanols A (1) and B (2), together with two known compounds, have been isolated from the twigs and leaves of Cephalotaxus fortunei Hook. Their structures were elucidated by using a combination of spectroscopic techniques and comparison of experimental and calculated electronic circular dichroism (ECD) data. To our knowledge, cephalotanols A and B represent the first rearranged norlignan glycosides with diphenylvinylcyclopropane core found in natural sources, of which biosynthetic pathways originating from co-occurring precursors 3S-4'-O-β-D-glucopyranosylhinokiresinol (3) and 3S-4''-O-β-D-glucopyranosylhinokiresinol (4) via di-π-methane rearrangement is proposed.

KEYWORDS
  • Cephalotaxus fortune
  • norlignan
  • diphenylvinylcyclopropane
  • structural elucidation
  • di-π-methane rearrangement

SUPPORTING INFORMATION


Supporting Information
Download File 345-RNP-2205-2461-SI.pdf (1.84 MB)