JOURNAL 2525


Records of Natural Products
VOLUME & ISSUE
Available Online: January 02,2023
PAGES
p.1 - 7
DOI ADDRESS
http://doi.org/10.25135/rnp.376.2207.2525
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Qi Zhou
  • Jiang Wan
  • Chunxiao Jiang
  • Yingpeng Tong
  • Zhen-Da Xie
  • Ting Wang
  • Dao-An Xiao
  • Zhi-Yong Xiao
  • Jin-Feng Hu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A previously undescribed phenolic glycoside (manglycoside A, 1), as well as 16 identified compounds (2–17), were isolated from the leaves and twigs of the 'vulnerable' plant Magnolia decidua (Magnoliaceae). Comprehensive spectroscopicinvestigation and chemical transformations revealed the structure of the previously unknown compound 1. Among the isolates, honokiol (6) and liriodenine (14) were discovered to exhibit anti-inflammatory activities in LPS-induced RAW 264.7cells via reducing nitric oxide (NO) formation, with IC50 values of 4.3 and 17.3 μM, correspondingly.

KEYWORDS
  • Magnoliaceae
  • Magnolia decidua
  • phenolic glycoside
  • aMnglycoside A
  • anti-inflammatory

SUPPORTING INFORMATION


Supporting Information
Download File 376-RNP-2207-2525-SI.pdf (775.34 KB)