JOURNAL 2194


Records of Natural Products
VOLUME & ISSUE
Available Online: November 15,2021
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.294.2109.2194
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Liancheng Xu
  • Shiping Wang
  • Xiang Ji
  • Changming Huang
  • Pengfei Hu
  • Weihuan Luo
  • Shan Liu
  • Yu Chen
  • Guodong Liu
  • Guanyi Cao
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Chemical investigation of the marine-derived fungus Aspergillus flavipes 297 led to the isolation and identification of three drimane-type sesquiterpenoids, asperflavinoid A (1) and (6-strobilactone-B) esters of (E,E)-6,7-dihydroxy-2,4-octadienoic acids (2 and 3). Asperflavinoid A (1) was characterized as unseparated diastereomers and its chemical structure was determined by spectroscopic analysis of NMR and MS data. In the cytotoxic assay, compound 1 showed promising inhibitory effects on HepG2 and MKN-45 cell lines.

KEYWORDS
  • Aspergillus flavipes
  • natural products
  • drimane sesquiterpenoids
  • cytotoxicity

SUPPORTING INFORMATION


Supporting Information
Download File 294-RNP-2109-2194-SI.pdf (984.85 KB)