JOURNAL 3301
Records of Natural Products
VOLUME & ISSUE
Available Online: November 10,2024
Available Online: November 10,2024
PAGES
p.1 - 8
p.1 - 8
DOI ADDRESS
http://doi.org/10.25135/rnp.484.2408.3301 (DOI number will be activated after the manuscript has been available in an issue.)
http://doi.org/10.25135/rnp.484.2408.3301 (DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 299 times.
Viewed 299 times.
AUTHORS
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Ping Song
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Huazhen Li
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Pengxin Liu
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Tognqing Li
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Yan Guo
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Ping Zhao
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Shiwen Kang
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Xingzhou Yang
GRAPHICAL ABSTRACT
ABSTRACT
Two new isoflavones, caraganin E (1) and caraganin F (2), were purified from 75% ethanolic extract of Caragana jubata roots, in company with ten known compounds. The chemical structures of two novel isoflavones were elucidated by NMR, HR-ESIMS and circular dichroism (CD). GLUT4 translocation activity was tested in L6 cells for all isolated compounds. Among them, compound 5 exhibited the best activity, increasing the fluorescence intensity by 3.25 folds. The results of the exploration may help us understand the chemotaxonomic variety of natural products in Caragana jubata and enhance the diversity of flavonoids.
KEYWORDS- Caragana
- Caragana jubata
- flavonoids
- GLUT4 translocation
