JOURNAL 3425
Records of Natural Products
Available Online: March 18,2025
p.1 - 12
http://doi.org/10.25135/rnp.502.2502.3425 (DOI number will be activated after the manuscript has been available in an issue.)
Viewed 110 times.
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Huynh Kim Yen
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Nguyen Trong Tuan
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Tran Thanh Men
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Chong Kim Thien Duc
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Ma Huu Dat
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Tran Truong Thi Tu
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Vu Thi Yen
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Nguyen Thi Thu Hau
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Vo Thanh Khang
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Nguyen Huu Khiem
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Thanh Q. C. Nguyen
GRAPHICAL ABSTRACT
ABSTRACT
Sphaerocoryne affinis is prevalent in numerous forests throughout Vietnam and has traditionally been used in the production of alcoholic beverages, as well as in folk medicines for treating various diseases. This study provided the first comprehensive investigation into the anti-oxidative stress and anti-inflammatory properties of S. affinis leaves. These results revealed that the S. affinis leaf extract and its fractions demonstrated notable antioxidant activity and stress-mitigating effects, as indicated by the prolonged lifespan of Drosophila melanogaster subjected to paraquat (PQ)-induced oxidative stress. Furthermore, the anti-inflammatory potential of S. affinis leaf extract and its ethyl acetate and hexane fractions was validated through their ability to inhibit NO secretion in LPS-stimulated RAW264.7 macrophage cells. Besides, 12 known bioactive compounds were isolated from the ethyl acetate fraction of S. affinis leaf extract, among which 8 compounds were identified for the first time in the genus Sphaerocoryne. These newly discovered compounds included allantoin, apigenin, rutin, isatin, 3-hydroxy-3-(2-oxopropyl)indolin-2-one, ethylene glycol dibenzoate, nicotiflorin, and 3,3',4,4'-tetrahydroxybiphenyl. These findings emphasized the potential of S. affinis leaves as a valuable source of bioactive compounds, paving the way for the development of innovative healthcare products and natural therapeutic interventions for various diseases.
KEYWORDS- antioxidant
- anti-oxidative stress
- anti-inflammatory
- chemical composition
- Sphaerocoryne affinis
