JOURNAL 2071


Records of Natural Products
VOLUME & ISSUE
Available Online: July 23,2021
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.267.2105.2071
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
Viewed 41 times.
AUTHORS
  • Zhangjun Xu
  • Yang Liu
  • Xiaowei Meng
  • Li Yang
  • Feng Shao
  • Ronghua Liu
  • Lanying Chen
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new neoflavonoid, (1R,8R,9R)-pterolinuse K (1) and six known neoflavonoids (2-7) were obtained from the heartwood of Dalbergia melanoxylon. The structure of the new neoflavonoid was elucidated by extensive NMR investigation, and X-ray crystallographic analysis. Compounds 3 and 6 showed anti-inflammatory activity with IC50 values 23.14 ± 0.30 and 19.46 ± 1.02 μΜ, respectively. Compounds 2, 3, 4, 6, 7 were showed cytotoxicity on Caco-2, MDA-MB-468, MDA-MB-231, CT26 cell lines. Moreover, compounds 2, 4 exhibited the significant activity in MDA-MB-231 cell lines with IC50 values 7.54 ± 1.50 and 7.23 ± 0.40 μΜ, respectively.

KEYWORDS
  • Dalbergia melanoxylon
  • neoflavonoids
  • anti-inflammatory activity
  • anti-tumor activity

SUPPORTING INFORMATION


Supporting Information
Download File 267-RNP-2105-2071-SI.pdf (2.55 MB)