Streptolactone A, A New Antibiofilm Lactone Derivative from Streptomyces sp. A31

Short Report

JOURNAL 3193

Records of Natural Products
VOLUME & ISSUE
Available Online: July 01,2024
PAGES
p.1 - 5
DOI ADDRESS
http://doi.org/10.25135/rnp.465-2404-3193
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Yan Xu
  • Yongjun Jiang
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A novel lactone derivative, named Streptolactone A (1), was unearthed from Streptomyces sp. A31 isolated from marine sediments. Its structure was elucidated through a comprehensive analysis of 1D, 2D NMR, and HRESIMS data. Assessment of its antibiofilm and antibacterial effects against P. aeruginosa was conducted via the microdilution and crystal violet staining method, revealing Streptolactone A’s notable potency in inhibiting biofilm formation.

 KEYWORDS
  • Streptomyces sp.
  • Streptolactone A
  • antimicrobial
  • antibiofilm

SUPPORTING INFORMATION

Supporting Information
Download File 465-RNP-2404-3193-SI.pdf (1.37 MB)