Tigliane-Type Diterpenoids from the Seeds of Croton tiglium

Original Article

JOURNAL 2455

Records of Natural Products
VOLUME & ISSUE
Available Online: July 29,2022
PAGES
p.1 - 6
DOI ADDRESS
http://doi.org/10.25135/rnp.344.2205.2455
(DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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AUTHORS
  • Lijuan Zhang
  • Fei Li
  • Jianyong Zhu
  • Qian Niu
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

A new tigliane-type diterpenoid (1) and three known analogues (2-4) were isolated from the seeds of Croton tiglium. Extensive spectroscopic analyses, especially the 2D NMR experiments were used to determine their structures. The absolute configuration of 1 was defined by single-crystal X-ray diffraction data. The cytotoxicity 1-4 was evaluated against melanoma cell line A375, and the results showed that compounds 1, 3, and 4 exhibited certain cytotoxicities.

 KEYWORDS
  • Croton tiglium
  • tigliane-type diterpenoid
  • cytotoxicity

SUPPORTING INFORMATION

Supporting Information
Download File 344-RNP-2205-2455-SI.pdf (950.47 KB)