JOURNAL


Organic Communications
VOLUME & ISSUE
Year: 2019 Issue: 1 (January-March)
PAGES
p.38 - 42
STATISTICS
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AUTHORS
  • Kadir Aksu
  • Bünyamin Özgeriş
  • Ferhan Tümer
  • 1 - Chemistry Department, Ordu University,
  • 2 - Department of Basic Sciences, Erzurum Technical University,
  • 3 -
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ABSTRACT


In this work, new N-substituted 2-aminopyrrole derivatives were synthesized. Firstly, we prepared crotonitriles by the condensation of malononitrile with arylmethylketones. Then, crotonitriles were converted to the bromocrotonitriles. Finally, the synthesis of new N-substituted 2-aminopyrrole derivates were successfully achieved by the cyclization reaction of the bromocrotonitriles with (R)-1-phenylethylamine by the using Gewald method.

 

 

KEYWORDS
  • : Pyrrole
  • aminopyrrole
  • Knoevenagel condensation
  • Gewald reaction

SUPPORTING INFORMATION


Supporting Information
Download File 4-55-OC-1903-1222-SI.pdf (2.58 MB)