Synthesis and -characterization of new N-substituted 2-aminopyrrole derivatives
Year: 2019 Issue: 1 (January-March)
p.38 - 42
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- 1 - Chemistry Department, Ordu University,
- 2 - Department of Basic Sciences, Erzurum Technical University,
- 3 -
In this work, new N-substituted 2-aminopyrrole derivatives were synthesized. Firstly, we prepared crotonitriles by the condensation of malononitrile with arylmethylketones. Then, crotonitriles were converted to the bromocrotonitriles. Finally, the synthesis of new N-substituted 2-aminopyrrole derivates were successfully achieved by the cyclization reaction of the bromocrotonitriles with (R)-1-phenylethylamine by the using Gewald method.
- : Pyrrole
- Knoevenagel condensation
- Gewald reaction