JOURNAL 1222


Organic Communications
VOLUME & ISSUE
Year: 2019 Issue: 1 January-March
PAGES
p.38 - 42
STATISTICS
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AUTHORS
  • Kadir Aksu
  • Bünyamin Özgeriş
  • Ferhan Tümer
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In this work, new N-substituted 2-aminopyrrole derivatives were synthesized. Initially, some crotonitriles were prepared by condensation of malononitrile with arylmethylketones, which was followed by conversion of them to the bromocrotonitriles. Finally, the synthesis of new N-substituted 2-aminopyrrole derivates were successfully achieved by cyclization of the bromocrotonitriles of (R)-1-phenylethylamine applying Gewald method.

 

 

KEYWORDS
  • : Pyrrole
  • aminopyrrole
  • Knoevenagel condensation
  • Gewald reaction

SUPPORTING INFORMATION


Supporting Information
Download File 4-55-OC-1903-1222-SI.pdf (2.58 MB)