Efficient synthesis and characterization of novel isoxazole derivatives including dihdyropyrazole and methanoisoindole moieties

Original Article

JOURNAL 1668

Organic Communications

VOLUME & ISSUE

Year: 2020 Issue: 2 April-June

PAGES

p.57 - 64

DOI ADDRESS

http://doi.org/10.25135/acg.oc.79.20.06.1668

STATISTICS

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AUTHORS

Meliha Burcu Gürdere
Fatih Ertürk
Yakup Budak
Mustafa Ceylan

GRAPHICAL ABSTRACT

ABSTRACT

Isoxazole and pyrazole derivatives have a wide range of biological activity and they are of great interest to medicinal chemist. In this study, the synthesis and characterization of a series of novel hybrid molecules containing pyrazole and isoxazole rings ((3aS,4S,4aR,7aS,8S,8aS)-6-(4-(1-acetyl-5-(4-(aryl/heteroaryl))-4,5-dihydro-1H-pyrazol-3-yl)phenyl)-3-methyl-4,4a,8,8a-tetrahydro-3aH-4,8-methanoisoxazo-lo [4,5-f] isoindole-5,7(6H,7aH)-dione derivatives) were reported.

KEYWORDS

Isoxazole
synthesis
characterization
NMR

SUPPORTING INFORMATION

Supporting Information

Download File A3-79-OC-2006-1668-SI.pdf (505 KB)