Synthesis of some 2-alkyl-5-(4-vinylphenyl)-2H-tetrazole compounds via the Wittig reaction and investigation by X-ray crystallography

Original Article

JOURNAL 2633

Organic Communications

VOLUME & ISSUE

Year: 2022 Issue: 4 October-December

PAGES

p.333 - 345

DOI ADDRESS

http://doi.org/10.25135/acg.oc.139.2211-2633

STATISTICS

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AUTHORS

Doğukan Doyduk
Yılmaz Yildirir

GRAPHICAL ABSTRACT

ABSTRACT

Tetrazoles are frequently used in industry and medicine. However, molecules that have both tetrazole and alkenyl groups are rare. For this purpose, new 2-alkyl-5-(4-vinylphenyl)-2H-tetrazole (BF5a-i, 63-99%) derivative compounds containing both styrene and tetrazole were synthesized with a high yield under mild conditions by the Wittig reaction. Their structures were verified by spectroscopic methods (FT-IR, 1H NMR, 13C-APT NMR, HRMS, and X-Ray crystallography (for BF5a).

KEYWORDS

Tetrazole
styrene
X-ray crystallography
Wittig
dehydration

SUPPORTING INFORMATION

Supporting Information

Download File A3-139-OC-2211-2633-SI.pdf (7.13 MB)