JOURNAL 544


Records of Natural Products
VOLUME & ISSUE
Year: 2015 Issue: 3 July-September
PAGES
p.305 - 311
STATISTICS
Viewed 1997 times.
AUTHORS
    Xiao-Xiao Huang, Qing-Bo Liu, Le Zhou, Sen Liu, Zhuo-Yang Cheng, Qian Sun, Ling-Zhi Li and Shao-Jiang Song
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Many tyrosinase inhibitors have been alleged to have serious side effects. To search for relatively mild and safe tyrosinase inhibitors, two new 8-O-4′ neolignans, named huangnin A (1) and B (2), and four known analogs (3-6) were isolated from the seeds of Crataegus pinnatifida. Their structures were elucidated by spectroscopic analyses (1D, 2D NMR, HRESIMS, CD and Rh 2(OCOCF 3) 4-induced CD). In addition, the in vitroantioxidant and anti-tyrosinase activities of all isolates were evaluated. The results showed that compound 5 has good antioxidant and promising tyrosinase-inhibiting activities.

KEYWORDS
  • Crataegus pinnatifida
  • Rosaceae
  • 8-O-4′ neolignans
  • antioxidant activity
  • tyrosinase-inhibiting activity