JOURNAL 197


Records of Natural Products
VOLUME & ISSUE
Year: 2017 Issue: 1 January-February
PAGES
p.1 - 8
STATISTICS
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AUTHORS
    Suraj K. Pokharel, Mary Snow Setzer, Stefanie E. Greenleaf, Noura S. Dosoky, Betsy R. Jackes and William N. Setzer
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Two known triterpenoids, friedelin and aglaitriol, and a new dammarane triterpenoid, aglaitriol 3-caffeate, have been isolated and identified in the chloroform bark extract of Drypetes acuminata P.I. Forst. (Putranjivaceae) from Paluma, north Queensland, Australia. The compounds were screened for antimicrobial and cytotoxic activity. Aglaitriol showed potent cytotoxic activity against three human tumor cell lines (MCF-7, MDA-MB-231, and 5637). Aglaitriol 3-caffeate showed moderate antibacterial activity against Staphylococcus aureus and Escherichia coli. A molecular docking analysis suggests topoisomerase II may be a likely protein target for aglaitriol.

KEYWORDS
  • Drypetes acuminata
  • dammarane
  • aglaitriol
  • aglaitriol 3-caffeate
  • cytotoxicity
  • antibacterial

SUPPORTING INFORMATION


Supporting Information
Download File 1-RNP-1606-413-SI.pdf (589.65 KB)