JOURNAL 940
Records of Natural Products
VOLUME & ISSUE
Year: 2019 Issue: 5 September-October
Year: 2019 Issue: 5 September-October
PAGES
p.424 - 428
p.424 - 428
STATISTICS
Viewed 2163 times.
Viewed 2163 times.
AUTHORS
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Meng-Yuan Jiang
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Chun-Tao Yang
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Xiao-Yun Pu
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Guangmiao Fu
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Wei Wang
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Yu-Xiao Li
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Lei Feng
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Zhi-Rui Niu
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Jian-Lin Tan
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Xiangzhong Huang
GRAPHICAL ABSTRACT
ABSTRACT
A new polyacetylene, heptadeca-8,16-dien-4,6-diyn-3,l0-diol (1) along with four known polyacetylenes, 1,2-dihydrodendroarboreol B (2), heptadeca-1,8-dien-4,6-diyn-3,l0-diol (3), 3R, 8S-falcarindiol (4) and 3R,8R-dehydrofalcarindiol (5) were isolated from the ethanol extract of Aralia dumetorum. The structures of the isolates were elucidated on the basis of 1D and 2D NMR spectrums and by comparison of the spectroscopic data with those reported for structurally related compounds. The α-glucosidase inhibitory activity of compounds 1-5 was evaluated using α-glucosidase inhibitory assay, in which all compounds displayed good inhibitory activity with IC50 values ranging from 4.2 ~ 36.2 μM..
KEYWORDS- Araliaceae
- Aralia dumetorum
- polyacetylenic compound
- α-glucosidase inhibitor
