JOURNAL 1342


Records of Natural Products
VOLUME & ISSUE
Year: 2020 Issue: 4 July-August
PAGES
p.276 - 285
STATISTICS
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AUTHORS
  • Melissa Salinas
  • Nicole Bec
  • James Calva
  • Jorge Ramirez
  • José Miguel Andrade
  • Christian Larroque
  • Giovanni Vidari
  • Chabaco Armijos
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Salvia pichinchensis Benth was collected in the South of Ecuador and the essential oil (EO) was distilled from aerial parts and analyzed by GC-MS and GC-FID. The physical properties, chemical composition, and cholinesterase inhibitory activity were determined. Six major components, all sesquiterpenes, were identified: cis-cadina-1(6),4-diene (17.11%) (1),γ-curcumene (13.75%) (2), (E)-caryophyllene (12.58%) (3), (E,E)-α-farnesene (10.00%) (4), α-gurjunene (9.46%) (5) and allo-aromadendrene (6.96%) (6). The EO showed an interesting selective inhibitory activity against the enzyme butyrylcholinesterase (50.70 μg/mL) and only low inhibitory activity against acetylcholinesterase (117.60 μg/mL). The chemical composition and butyrylcholinesterase activity of the EO of S. pichinchensis Benth was reported for first time.

KEYWORDS
  • Salvia pichinchensis
  • essential oil
  • GC-MS analysis
  • in vitro ChE inhibitory activity
  • cis-cadina-1(6),4-diene

SUPPORTING INFORMATION


Supporting Information
Download File A5-164-RNP-1907-1342-SI.pdf (54.63 KB)