JOURNAL 186


Organic Communications
VOLUME & ISSUE
Year: 2011 Issue: 4 October-December
PAGES
p.82 - 93
STATISTICS
Viewed 1171 times.
AUTHORS
    Sanath Kumar Goud Palusa, Rajgopal H.Udupi, Himabindu. and Ajjanna M Sridhara
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GRAPHICAL ABSTRACT


ABSTRACT


Novel pyrimidine substituted 1,3,4-oxadiazole derivatives (11a-k) were synthesized from the condensation of different substituted aromatic carboxylic acids with substituted pyrimidine carboxy hydrazide using POCl3 as condensing agent. Their structures were characterized by physical and spectral studies. The synthesized compounds were evaluated for their in vitro antimicrobial and anti-inflammatory activity. Some of the newly synthesized compounds showed good antimicrobial and anti-inflammatory activities.

KEYWORDS
  • 1
  • 3
  • 4-oxadiazole
  • pyrimidine
  • antibacterial
  • antifungal
  • anti-inflammatory.