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Iminium salt mediated nitro decarboxylation of α, β-unsaturated acids for the synthesis of β–nitro styrenes under non–conventional conditions

Original Article

JOURNAL 1708

Organic Communications
VOLUME & ISSUE
Year: 2012 Issue: 2 April-June
PAGES
p.42 - 49
DOI ADDRESS
STATISTICS
Viewed 1611 times.
AUTHORS
    Mukka Satish Kumar, Purugula Venkanna, Soma Ramgopal, KolaRamesh, Marri Venkateswarlu and Kamatala Chinna Rajanna
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Iminium Salt Mediated Nitro decarboxylation of alpha,beta Unsaturated Acids has been taken up under conventional and non – conventional conditions. Vilsmeier - Haack (VH) Reagent is used as a source for the generation of iminium salt. Equimolar mixture of either DMF/SOCl2 or DMF/POCl3 is used for the preparation of VH reagent. Reactions afforded good yield of products under conventional conditions with longer reaction times. Microwave irradiated reactions not only reduced the reaction times but enhanced the yield of products from good to excellent.

 KEYWORDS
  • Nitration
  • α, β-unsaturated acids
  • vilsmeier-haack (VH) reagent
  • solvent- free
  • microwave.

SUPPORTING INFORMATION

Supporting Information
Download File 5-OC-1107-209_supporting.pdf (27.24 KB)