A Simple and efficient protocol for the synthesis of quinoxalines catalyzed by pyridine

Original Article

JOURNAL 192

Organic Communications

VOLUME & ISSUE

Year: 2013 Issue: 1 January-March

PAGES

p.23 - 30

STATISTICS

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AUTHORS

Sachin B. Wadavrao, Ramesh S. Ghogare and A. Venkat Narsaiah

GRAPHICAL ABSTRACT

ABSTRACT

A simple and efficient protocol has been developed for the synthesis of quinoxalines. In the synthesis, the reaction of 1,2-phenylenediamines and phenacyl bromide were carried out using pyridine as a catalyst in THF at room temperature to give quinoxalines. This method is applicable to a variety of substrates to afford the corresponding derivatives in excellent yields.

KEYWORDS

Phenacyl bromide
1
2-phenylenediamines
pyridine
quinoxalines.