JOURNAL 191


Organic Communications
VOLUME & ISSUE
Year: 2013 Issue: 1 January-March
PAGES
p.12 - 22
STATISTICS
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AUTHORS
    Goverdhan Gilla, Raghupathi Reddy Anumula, Sampath Aalla, Himabindu Vurimidi, Mahesh Reddy Ghanta
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GRAPHICAL ABSTRACT


ABSTRACT


Tadalafil (Cialis) is a potent and selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type-5 (PDE-5) and it is administered orally for the treatment of erectile dysfunction (ED). Two synthetic schemes were evaluated to study the impurity profile of tadalafil. Six impurities were detected in the bulk substance (prepared by two methods) at a level of 0.1-0.15%. Identification, synthesis, characterization of impurities (related substances) and metabolite and origin of their formation is described .

KEYWORDS
  • Tadalafil
  • PDE-5 inhibitor
  • metabolite
  • related substances
  • two synthetic schemes.