Bleaching earth clay (pH 12.5): A novel and reusable catalyst for rapid synthesis of 7-Hydroxy 4-Styryl coumarin derivatives and their antihelmintic activity

Original Article

JOURNAL 3295

Organic Communications

VOLUME & ISSUE

Year: 2013 Issue: 2 April-June

PAGES

p.95 - 101

DOI ADDRESS

STATISTICS

Viewed 149 times.

AUTHORS

Rahul D. Kamble, Govind V. Jawadwar, Snehalkumar D. Patil1, Shrikant V. Hese1, Ashok P. Acharya, Bhaskar S. Dawane and Sanjay S. Pekamwar

GRAPHICAL ABSTRACT

ABSTRACT

7-hydroxy 4-styryl coumarin derivatives were synthesized by Knovengel condensation of 7-hydroxy 4-methyl coumarin with aldehydes by using novel and reusable catalyst bleaching earth clay (pH12.5) in PEG- 400 as green reaction solvent, followed by the Mannich reaction. The synthesized compounds were evaluated for their in vitro antihelmintic activity and it was found that the synthesized compounds showed good antihelmintic activity.

KEYWORDS

7-hydroxy 4-styryl coumarin derivatives
bleaching earth clay (pH12.5)
PEG-400
antihelmintic activity
albendazole