Synthesis and antimicrobial activity of some novel fused heterocyclic moieties

Original Article

JOURNAL 3293

Organic Communications

VOLUME & ISSUE

Year: 2013 Issue: 2 April-June

PAGES

p.78 - 86

DOI ADDRESS

STATISTICS

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AUTHORS

Nareshvarma Seelam, Satya P. Shrivastava and Somarouthu Prasanthi

GRAPHICAL ABSTRACT

ABSTRACT

Here a new class of 1, 3, 4-thiadiazoles which are incorporating with isoxazolo-thiazole moieties were synthesized by the reaction of chalcone derivatives of [1, 3, 4] thiadiazol-2-yl)-thiazolidin-4-one with hydroxylamine hydrochloride. The chemical structures of these compounds were confirmed by IR, NMR (1H & 13C) and mass spectral studies. The new synthesized compounds were evaluated for their antimicrobial activity. The final results revealed that some of the compounds were exhibited well antimicrobial activity compared to the
standard drugs.

KEYWORDS

Thiadiazole
pyrazole
thiazolidinones
antimicrobial studies
anti-tuberculosis studies