Concise synthesis of a novel antifungal agent 4-methoxydecanoic acid

Original Article

JOURNAL 3297

Organic Communications

VOLUME & ISSUE

Year: 2013 Issue: 4 October-December

PAGES

p.134 - 138

STATISTICS

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AUTHORS

Pagudala Narsimha and Akkirala Venkat Narsaiah

GRAPHICAL ABSTRACT

ABSTRACT

4-Methoxy decanoic acid is belongs to a fatty acid family and has a novel anti- fungal activity. The aliphatic molecule has been synthesized in seven steps with an overall yield 41%. The synthesis was started from a commercially available epichloro hydrin and all the reactions were very clean.

KEYWORDS

Epichlorohydrin
Grignard reaction
methyliodide
oxidation
hydrolysis