Synthesis and antifungal evaluation of imines derived from 3-Amino-2-isopropyl-3H-quinazolin-4-one

Original Article

JOURNAL 3298

Organic Communications

VOLUME & ISSUE

Year: 2013 Issue: 4 October-December

PAGES

p.139 - 147

STATISTICS

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AUTHORS

Idris Karakaya, Semistan Karabuga, Zeynep Ulukanli and Sabri Ulukanli

GRAPHICAL ABSTRACT

ABSTRACT

Novel Schiff bases were synthesised using 3-aminoquinazolinone (1) and a variety of aldehydes in the presence of acetic acid as solvent. Antifungal evaluation of the compounds was carried out by the agar dilution method. Among the all compounds prepared, quinazolinone itself showed the best fungiostatic activity against all filamentous fungi.

KEYWORDS

Quinazolinone
schiff bases
Imines
antifungal
antimicrobial