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Eco-friendly synthesis of novel indeno-pyrazole derivatives and their in-vitro antimicrobial screening

Original Article

JOURNAL 681

Organic Communications
VOLUME & ISSUE
Year: 2014 Issue: 2 April-June
PAGES
p.68 - 76
STATISTICS
Viewed 2496 times.
AUTHORS
    Ashok P. Acharya, Rahul D. Kamble, Shrikant V. Hese, Shuddhodan N. Kadam, Rajesh N. Gacche and Bhaskar S. Dawane
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GRAPHICAL ABSTRACT

ABSTRACT

In the present communication a series of novel indeno-pyrazole derivatives were synthesized by the reaction of α, β-unsaturated ketones with phenyl hydrazine in polyethylene glycol-400 (PEG-400) and few drop of acetic acid. The newly synthesized compounds were characterized and confirmed by IR, 1H-NMR, 13C-NMR and mass spectral data. The results obtained indicate the significance of indeno-pyrazole derivatives as potent scaffold for designing novel and broad spectrum antimicrobials.

 KEYWORDS
  • Indeno -Pyrazole derivatives
  • bleaching earth clay (pH12.5)
  • Polyethylene glycol-400(PEG-400)
  • Antimicrobial activity