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Some new azole type heterocyclic compounds as antifungal agents

Original Article

JOURNAL 686

Organic Communications
VOLUME & ISSUE
Year: 2014 Issue: 4 October-December
PAGES
p.114 - 122
STATISTICS
Viewed 2146 times.
AUTHORS
    Mohammad Russell, and Mohammad Ikthair Hossain Soiket
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Schiff’s base1-[(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)]ethanone thiosemicarbazone (compound 1A) wasprepared by condensation of 1-(2,4-difluorophenyl)-2- [1 (H)-1,2,4-triazol-1-yl]ethanone (1)with thiosemicarbazide. The compound 1A, on reaction with α-halogenoketones yielded 1-(2, 4-difluorophenyl)-2-[(1H)-1,2,4-triazol-1-yl] ethanone [2-[4-halogenophenyl] thiazolyl]hydrazone.Anti-fungal activity of all the compounds has been tested against four fungal organism: C. albicans , Colletotrichum spp., A. nigar and Fusarium spp. commonly responsible for fungal infections in Bangladesh.

 KEYWORDS
  • chiff’s bases
  • compound 1A
  • 1-(2
  • 4-difluorophenyl)-2- [1 (H)-1
  • 2
  • 4-triazol-1-yl] ethanone (1)
  • α-halogenoketones
  • 1-(2
  • 4-difluorophenyl)-2-[(1H)-1
  • 2
  • 4-triazol-1-yl] ethanone [2-[4-halogenophenyl] thiazolyl] hydrazone
  • Anti-fungal activity