Synthesis and in vitro cytotoxic effect of some novel 4H-furo [3,2–c]pyran-4-one derivatives

We report a series of novel 4H-furo[3,2–c]pyran-4-one derivatives. Structures of synthesized compounds were determined by the IR, NMR, elemental analysis and X-ray diffraction method. All the compounds were tested for genotoxicity in human lymphocytes cultures. Sister chromatid exchange (SCE), micronucleus (MN), mitotic index (MI) and replication index (RI) tests are used in toxicological screening for potential cytotoxic and genotoxic effects. According to the results of the genotoxic tests, the 4H-furo[3,2–c]pyran-4-one derivatives induce the frequencies of these parameters. The results showed that these compounds are potential genotoxic and cytotoxic compounds at high concentrations (especially 1 and 2 mg/mL).