JOURNAL 836


Organic Communications
VOLUME & ISSUE
Year: 2018 Issue: 1 January-March
PAGES
p.62 - 67
STATISTICS
Viewed 1386 times.
AUTHORS
    Bala Murali Krishna Khandapu , Lourdu Rani Bhavanam , Naresh Polam and Hari Babu Bollikolla
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Preparation of a biologically active benzofuran derivative ethyl 2-(4-fluorophenyl)-5-hydroxy-6-nitro - benzofuran-3-carboxylate from commercially available starting materials 2- bromo-4-methoxy-phenol and para- fluorophenylacetylene is described in four steps with good yields. The final compound and all the intermediates reported in the method were characterized by spectroscopic techniques. Finally, the target molecule and its methyl derivative were tested for their anticancer activity and were found to be 95.2 μg/mL and 8.5 μg/mL (IC 50) respectively against HCT 116 cell line.

KEYWORDS
  • Cytotoxicity
  • HCT116
  • ethyl 2-(4-fluorophenyl)-5-hydroxy-6- nitrobenzofuran-3- carboxylate
  • 2-bromo-4-methoxy-phenol
  • MTT

SUPPORTING INFORMATION


Supporting Information
Download File 7-OC-1802-066-SI.pdf (1.2 MB)