JOURNAL 833


Organic Communications
VOLUME & ISSUE
Year: 2018 Issue: 1 January-March
PAGES
p.34 - 45
STATISTICS
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AUTHORS
    Mavallur Varalakshmi and Chamarthi Nagaraju
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A new series of nucleoside substituted perhydro-1λ 5-[1,3,2]diazaphospholo[1,5-a]pyridine-3-thione derivatives 4(a-j) was synthesized by a one-pot two-step process. It involves the formation of key intermediate, 1-chloroperhydro-1λ 5-[1,3,2]diazaphospholo [1,5-a]pyridine-1-thione (3) and its subsequent reaction with various nucleosides to obtain the title products 4(a-j). Structures of all the newly synthesized compounds were elucidated by spectral analysis. Compound (4b)linked with zidovudine exhibited highest antiviral and antimicrobial activities as compared to other nucleoside derivatives.

KEYWORDS
  • 2(±)-Aminomethyl piperidine
  • thiophosphoryl chloride
  • nucleosides
  • antiviral activity
  • antimicrobial activity