PREVIOUS ARTICLE
NEXT ARTICLE

Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity

Original Article

JOURNAL 1853

Organic Communications
VOLUME & ISSUE
Year: 2020 Issue: 4 October-December
PAGES
p.175 - 183
DOI ADDRESS
http://doi.org/10.25135/acg.oc.86.20.10.1853
STATISTICS
Viewed 1712 times.
AUTHORS
  • Cenk A. Andac
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Herein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-propyl]pyrimidine-2,4-(1H,3H)-dione (6) (67% yield) is described. After successful microwave synthesis steps, MTT cytotoxicity experiments gave rise to greater anticancer effect of compound 6 in MCF-7 human breast adenocarcinoma cell line (IC50= 1.35 µM) as compared to literature values for tamoxifen (IC50= 8.3 µM) and doxorubicin (IC50= 27 µM).

 KEYWORDS
  • Microwave synthesis
  • phenothiazine derivatives
  • 1-(3-(2-methylsulfanyl-10H-phenothiazine-10-yl)-prop-1-yl)pyrimidine-2,4(1H,3H)-dione
  • NMR
  • IC50
  • MCF-7

SUPPORTING INFORMATION

Supporting Information
Download File A4-86-OC-2010-1853-SI.pdf (739.72 KB)