JOURNAL 2139


Organic Communications
VOLUME & ISSUE
Year: 2021 Issue: 3 July-September
PAGES
p.294 - 299
STATISTICS
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AUTHORS
  • Murat Sunkur
  • Sara Aydın
  • Tarık Aral
  • Besir Dağ
  • Ramazan Erenler
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


N,N′-Dicyclohexylcarbodiimide  and hydroxybenzotriazole  mediated amination of free COOH group of N-tert-butyloxyoxycarbonyl-L-isoleucine 1 with three aromatic amines  gave the corresponding  amides 2a-c.  Deprotection of N-tert- butyloxyoxycarbonyl groups of 2a-c with AcOH yielded the related amine derivatives 3a-c. The amidation of the free NH2 groups of (3a-c) with phthaloyl dichloride yielded the bis-amide products 4a-c. The synthesized compounds were purified by crystallization and their structures were elucidated by spectroscopic methods such as 1H-HMR, 13C-NMR, FTIR, and micro analysis.

KEYWORDS
  • Amides
  • tetraamides
  • N-boc-deprotection
  • coupling reaction
  • spectroscopy
  • heterocyclic

SUPPORTING INFORMATION


Supporting Information
Download File A7-112-OC-2107-2139-SI.pdf (2.67 MB)