JOURNAL 2341
Organic Communications
VOLUME & ISSUE
Year: 2022 Issue: 1 January-March
Year: 2022 Issue: 1 January-March
PAGES
p.44 - 58
p.44 - 58
STATISTICS
Viewed 1376 times.
Viewed 1376 times.
GRAPHICAL ABSTRACT
ABSTRACT
A simple and efficient general procedure has been developed for the synthesis of three-component reaction methodology of 2,4,5-trisubstituted imidazoles by using benzil, ammonium acetate and various aromatic aldehydes. In this methodology, mandelic acid is used as a novel and efficient organo-catalyst in catalytic amount under solvent-free conditions for preparation of variety of 2,4,5-trisubstituted imidazoles derivatives in excellent yields. All products have been characterized by 1H NMR and 13C NMR spectroscopy, IR spectroscopy and mass spectrometry. This method provides versatile advantages of organo-catalyst such as economical, nontoxic, highly stable, readily and easily available as well as solvent-free reaction conditions.
KEYWORDS- 2,4,5-trisubstituted imidazoles
- benzil
- ammonium acetate
- mandelic acid
- organo-catalyst
- solvent-free
