Synthesis of new heterocycles via methylenebis(2-(2-methoxyphenyl)thiazolidin-4-one) as potential anticancer agents

Original Article

JOURNAL 2353

Organic Communications

VOLUME & ISSUE

Year: 2022 Issue: 2 April-June

PAGES

p.96 - 107

DOI ADDRESS

http://doi.org/10.25135/acg.oc.130.2202.2353

STATISTICS

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AUTHORS

Avula Srinivas
Sonti Reddy Rajitha

GRAPHICAL ABSTRACT

ABSTRACT

NaOAc catalyzed condensation of bis(2-(2-methoxyphenyl)thiazolidin-4-one) with p-methoxybenzaldehyde in AcOH gave the corresponding chalcones. Cyclization of the synthesized chalcones with NH2OH by refluxing in AcOH afforded the related isoxazoles fused with thiazoles. All the synthesized isoxazoles were evaluated against different tumor cell lines. Almost all compounds showed activity against prostate cancer cell lines.

KEYWORDS

Bis thiazolo isoxazoles
cytotoxic activity
Knovenagal condensation
cyclisation

SUPPORTING INFORMATION

Supporting Information

Download File A2-130-OC-2202-2353-SI.pdf (657.16 KB)