Efficient one-pot cascade synthesis of pyrazolopyridazine in PEG-400

Communication

JOURNAL 2408

Organic Communications

VOLUME & ISSUE

Year: 2022 Issue: 3 July-September

PAGES

p.297 - 303

DOI ADDRESS

http://doi.org/10.25135/acg.oc.135.2204.2408

STATISTICS

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AUTHORS

Ranjit Gayake
Vasant Jagrut
Vivek Humne

GRAPHICAL ABSTRACT

ABSTRACT

A one-pot cascade synthesis of pyrazolopyridazine from 4-(bromo(aryl)methyl)-3-chloropyridazines in PEG-400, in an ecofriendly solvent system has been developed. A series of pyrazolopyridazines (2a-i) were synthesized by using bidentate electron-donor ligand in good yield (60-85%). The present cascade protocol included nucleophilic substitution, ring closer and oxidative aromatization in single precedential step.

KEYWORDS

Pyrazolopyridazine
heterocyclic compound
cascade
PEG-400

SUPPORTING INFORMATION

Supporting Information

Download File A6-135-OC-2204-2408-SI.pdf (1.52 MB)