JOURNAL 2653


Organic Communications
VOLUME & ISSUE
Year: 2023 Issue: 1 January-March
PAGES
p.11 - 23
STATISTICS
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AUTHORS
  • Pelin Süzgün
  • Sevil Şenkardeş
  • Merve Gürboğa
  • Özlem Bingöl Özakpınar
  • Ş.Güniz Küçükgüzel
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


In this study, the synthesis and characterization of 2-(2-fluorobiphenyl-4-yl)-N´-[(substituted methylene]propanehydrazides (3a-s) and 2-(2-fluoro-[1,1'-biphenyl]-4-yl)-N-(5-methyl-2-(substituted aryl)-4-oxothiazolidin-3-yl)propanamides (4a-s) are described and also the antiproliferative effect of the compounds on  HT-29,  HeLa, A549 and MCF-7 cancer cell lines is investigated. Additionally, mouse embryonic fibroblast cells NIH3T3 were also evaluated to determine the selectivity. The results showed that the identified compounds did not cause any toxicity against NIH3T3 cell line. Moreover, N-(2-(3,5-Bis(trifluoromethyl)phenyl)-5-methyl-4-oxothiazolidin-3-yl)-2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanamide (4h) had the most growth inhibitory effect (55.97% inhibition) on HT-29 colorectal adenocarcinoma cell line. The results obtained from the study show that the compound 4h, which has no cytotoxic effect on normal cells, may be an alternative in the treatment of colon cancer.

KEYWORDS
  • Hydrazone
  • 4-thiazolidinone
  • MTT
  • antiproliferative activity
  • flurbiprofen

SUPPORTING INFORMATION


Supporting Information
Download File A2-144-OC-2212-2653-SI.pdf (4.69 MB)