JOURNAL 2741


Organic Communications
VOLUME & ISSUE
Year: 2023 Issue: 2 April-June
PAGES
p.54 - 74
STATISTICS
Viewed 1230 times.
AUTHORS
  • Ensaf Alwan
  • Marwa Bayoumy
  • Rafat M. Mohareb
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GRAPHICAL ABSTRACT


ABSTRACT


In this review, we demonstrated the synthesis of isatin derivative 3 according to the Mannich reaction.  Moreover, the synthesis of substituted enamines 6a-b using urea catalysts were studied. Additionally, the synthesis of azepanes, piperidines, pyrrolidines, pyrazole, pyridine and pyrimidine derivatives were reported. Furthermore, the synthesis of triazolium salts (34), enamines derivatives 39 and 40, tetrapyrazinoporphyrazine magnesium complex (43), ligands 49 and 50, optically active α-amino acids 62a, lactam derivative 67, and its isomer α-camphidone (68), camphor dimethyl DL‑tartrate (Ct diester) (70), and thiazole derivatives from camphor monoterpenes were realized. The biological activities of many compounds were studied toward human cancer cell lines, influenza virus, Streptococcus pneumoniae, Klebsiella pneumoniae, Staphylococcus aureus, Pseudomonas aeruginosa, Methicillin-Resistant Staphylococcus aureus (MRSA), Escherichia coli, Bacillus cereus, Bacillus subtilis and vaccinia virus, showing interesting results.

KEYWORDS
  • Camphor
  • pyrazole
  • dimethyl DL tartrate
  • thiazole
  • biological activity