JOURNAL 2696
Organic Communications
VOLUME & ISSUE
Year: 2023 Issue: 2 April-June
Year: 2023 Issue: 2 April-June
PAGES
p.75 - 86
p.75 - 86
STATISTICS
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Viewed 1075 times.
GRAPHICAL ABSTRACT
ABSTRACT
A series of novel hybrid compounds was synthesized where 2′-hydroxyacetophenone and N-alkylated thiotetrazole were coupled via methylene spacers of different lengths. The structures of the compounds were characterized by spectroscopic techniques, including the 1H- and 13C-NMR, FT-IR, and HRMS methods. The antimicrobial activities of the title compounds were evaluated against clinical isolates of Gram-positive and negative bacterial and fungal species. All compounds showed a broad spectrum of antimicrobial activity and inhibited all bacteria and fungi that tested with MIC values ranging from 4 to 128 µg/ml. 4a and 5d were the most active antibacterial members.
KEYWORDS- Hydroxyacetophenone
- tetrazole
- hybrid
- antimicrobial activity
