JOURNAL 2696


Organic Communications
VOLUME & ISSUE
Year: 2023 Issue: 2 April-June
PAGES
p.75 - 86
STATISTICS
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AUTHORS
  • Ali DİŞLİ
  • Esin Eylem Yucesoy
  • Ali Ozturk
  • Gulay Dilek
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


A series of novel hybrid compounds was synthesized where 2′-hydroxyacetophenone and N-alkylated thiotetrazole were coupled via methylene spacers of different lengths. The structures of the compounds were characterized by spectroscopic techniques, including the 1H- and 13C-NMR, FT-IR, and HRMS methods. The antimicrobial activities of the title compounds were evaluated against clinical isolates of Gram-positive and negative bacterial and fungal species. All compounds showed a broad spectrum of antimicrobial activity and inhibited all bacteria and fungi that tested with MIC values ranging from 4 to 128 µg/ml. 4a and 5d were the most active antibacterial members.

KEYWORDS
  • Hydroxyacetophenone
  • tetrazole
  • hybrid
  • antimicrobial activity

SUPPORTING INFORMATION


Supporting Information
Download File 2-148-OC-2302-2696-SI.pdf (1.08 MB)