JOURNAL 2762


Organic Communications
VOLUME & ISSUE
Year: 2023 Issue: 2 April-June
PAGES
p.87 - 97
STATISTICS
Viewed 1212 times.
AUTHORS
  • Ganesh V. Shitre
  • Anisha R. Patel
  • Ramesh S. Ghogare
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones has been achieved via Knoevenagel condensation using three-component coupling reaction of aromatic aldehyde, ethyl acetoacetate and hydroxylamine hydrochloride in Gluconic acid aqueous solution (50 wt % GAAS). In this methodology, Gluconic acid aqueous solution used as reaction medium as well as catalyst and it can be recycled and reused several times without loss of its a significant efficacy. All compounds have been confirmed by 1H NMR, 13C NMR, IR spectroscopy and mass spectrometry.

KEYWORDS
  • Green synthesis
  • gluconic acid aqueous solution
  • bio-based green solvent
  • Knoevenagel condensation
  • 3,4-disubstituted isoxazol-5(4H)-ones.

SUPPORTING INFORMATION


Supporting Information
Download File 3-151-OC-2304-2762-SI.pdf (684.16 KB)