JOURNAL 2762
Organic Communications
VOLUME & ISSUE
Year: 2023 Issue: 2 April-June
Year: 2023 Issue: 2 April-June
PAGES
p.87 - 97
p.87 - 97
STATISTICS
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Viewed 1212 times.
GRAPHICAL ABSTRACT
ABSTRACT
Green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones has been achieved via Knoevenagel condensation using three-component coupling reaction of aromatic aldehyde, ethyl acetoacetate and hydroxylamine hydrochloride in Gluconic acid aqueous solution (50 wt % GAAS). In this methodology, Gluconic acid aqueous solution used as reaction medium as well as catalyst and it can be recycled and reused several times without loss of its a significant efficacy. All compounds have been confirmed by 1H NMR, 13C NMR, IR spectroscopy and mass spectrometry.
KEYWORDS- Green synthesis
- gluconic acid aqueous solution
- bio-based green solvent
- Knoevenagel condensation
- 3,4-disubstituted isoxazol-5(4H)-ones.