Green synthesis of 3,4-disubstituted isoxazol-5(4H)-one using Gluconic acid aqueous solution as an efficient recyclable medium.

Original Article

JOURNAL 2762

Organic Communications

VOLUME & ISSUE

Year: 2023 Issue: 2 April-June

PAGES

p.87 - 97

DOI ADDRESS

http://doi.org/10.25135/acg.oc.151.2304.2762

STATISTICS

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AUTHORS

Ganesh V. Shitre
Anisha R. Patel
Ramesh S. Ghogare

GRAPHICAL ABSTRACT

ABSTRACT

Green synthesis of 3,4-disubstituted isoxazol-5(4H)-ones has been achieved via Knoevenagel condensation using three-component coupling reaction of aromatic aldehyde, ethyl acetoacetate and hydroxylamine hydrochloride in Gluconic acid aqueous solution (50 wt % GAAS). In this methodology, Gluconic acid aqueous solution used as reaction medium as well as catalyst and it can be recycled and reused several times without loss of its a significant efficacy. All compounds have been confirmed by 1H NMR, 13C NMR, IR spectroscopy and mass spectrometry.

KEYWORDS

Green synthesis
gluconic acid aqueous solution
bio-based green solvent
Knoevenagel condensation
3,4-disubstituted isoxazol-5(4H)-ones.

SUPPORTING INFORMATION

Supporting Information

Download File 3-151-OC-2304-2762-SI.pdf (684.16 KB)