An efficient synthesis of quinoxaline derivatives using HCTU as catalyst in DMF

Original Article

JOURNAL 2876

Organic Communications

VOLUME & ISSUE

Year: 2023 Issue: 4 October-December

PAGES

p.187 - 196

DOI ADDRESS

http://doi.org/10.25135/acg.oc.160.2308.2876

STATISTICS

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AUTHORS

Nitin A. Sasane
Bhushan B. Popatkar
Gangadhar A. Meshram

GRAPHICAL ABSTRACT

ABSTRACT

We have successfully developed a novel and efficient method for the synthesis of quinoxaline and its derivatives. This method involves the reaction between various 1,2-diamines and substituted phenacyl bromides in the presence of a catalytic amount of O-(1H-6-Chlorobenzotriazole-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HCTU) in dimethylformamide (DMF) as the solvent. This protocol offers several advantages, including mild reaction condition, short reaction time and moderate to high yield of the desired product(s).

KEYWORDS

Quinoxalines
HCTU
1,2-Diamines
phenacyl bromides

SUPPORTING INFORMATION

Supporting Information

Download File A2-160-OC_2308_2876-SI.pdf (3.15 MB)