JOURNAL 2893
Organic Communications
VOLUME & ISSUE
Year: 2023 Issue: 4 October-December
Year: 2023 Issue: 4 October-December
PAGES
p.204 - 211
p.204 - 211
STATISTICS
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Viewed 724 times.
GRAPHICAL ABSTRACT
ABSTRACT
In this study, a synthetic route to access unsymmetrical ditetrazoles was developed. By using this method, the first examples of unsymmetrical thioditetrazole compounds were synthesized. In vitro, antibacterial efficacy studies were carried out for all the thioditetrazoles and their precursor thiotetrazoles against ten bacteria. The synthesized compounds showed a strong antibacterial effect against pathogenic Gram-negative bacteria, especially Escherichia coli, Salmonella typhi and Pseudomonas aeruginosa (up to 21 mm).
.KEYWORDS
- Tetrazole
- thiotetrazole
- dithiotetrazole
- antibacterial activity
- antifungal activity
