Two efficient methods for the total synthesis of the natural diarylheptanoid 7-(4-hydroxyphenyl)-1-phenylheptan-3-one

Original Article

JOURNAL 3254

Organic Communications

VOLUME & ISSUE

Year: 2024 Issue: 2 April-June

PAGES

p.115 - 122

DOI ADDRESS

http://doi.org/10.25135/acg.oc.169.24.05.3254

STATISTICS

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AUTHORS

Esra Gürel
Turgut Kaya
Neslihan Celebioglu
Hatice Seçinti Klopf
Hasan Seçen

GRAPHICAL ABSTRACT

ABSTRACT

Diarylheptanoids are compounds with an ArC7Ar structure, where two aromatic rings are connected by a seven-carbon chain. To date, over 500 structurally diverse diarylheptanoids have been isolated from nature. These compounds are generally minor secondary metabolites found in plants. Natural diarylheptanoids possess a wide range of biological activities, making their short and efficient total synthesis important for enabling further research on these substances. In this study, two efficient synthesis methods developed for the compound 7-(4-hydroxyphenyl)-1-phenylheptan-3-one, which is isolated as a minor component from Alpinia officinarum, are presented.

KEYWORDS

Linear diarylheptanoid
7-(4-hydroxyphenyl)-1-phenylheptan-3-one
total synthesis
Alpinia officenarum
natural product

SUPPORTING INFORMATION

Supporting Information

Download File A3-169-OC-2405-3254-SI.pdf (871.96 KB)