Efficient synthesis of benzylidene semicarbazones from aromatic aldehydes by urea-hydrogen peroxide (UHP)

Communication

JOURNAL 3177

Organic Communications

VOLUME & ISSUE

Year: 2024 Issue: 2 April-June

PAGES

p.123 - 127

DOI ADDRESS

http://doi.org/10.25135/acg.oc.166.2403.3177

STATISTICS

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AUTHORS

Ali Reza Molla Ebrahimlo

GRAPHICAL ABSTRACT

ABSTRACT

A facile and useful method for synthesis of 1-benzylidene semicarbazones was introduced in this work. The reaction of synthesis of the corresponding 1-benzylidene semicarbazone derivatives is carried out in the presence of acetonitrile-UHP/NH4OAc. In this method, NH4OAc was used as a source of ammonia and urea-hydrogen peroxide (UHP) as reagent. The key advantages of this process are elimination of semicarbazide, good yields and cheap reagents. All products were characterized by common techniques (infrared, 1H NMR, and melting point).

KEYWORDS

benzylidene semicarbazone
UHP
aromatic aldehydes
acetonitrile

SUPPORTING INFORMATION

Supporting Information

Download File A4-166-OC-2403-3177-SI.pdf (1.48 MB)