JOURNAL 3412
Organic Communications
VOLUME & ISSUE
Available Online: March 22,2025
Available Online: March 22,2025
PAGES
p.1 - 11
p.1 - 11
DOI ADDRESS
http://doi.org/10.25135/acg.oc.182.2501.3412 (DOI number will be activated after the manuscript has been available in an issue.)
http://doi.org/10.25135/acg.oc.182.2501.3412 (DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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GRAPHICAL ABSTRACT
ABSTRACT
In the present study, we have developed an efficient N-acetylation method of anilines under green and eco-friendly conditions, where Baker’s Yeast (BY) was used as biocatalyst. The results of this study clearly demonstrate towards the N-acetylation of only anilines to form acetanilides (3a-i) with acetic anhydride in good to excellent yield. Interestingly, acetylation of phenol/thiophenol, aliphatic amines/heterocyclic amines and amino acids failed under the same conditions. This N-acetylation reaction with substrate-selective follows simple procedure and requires simple work up. Thus, we can conclude that the present method is a simple, efficient, substrate selective and eco-friendly.
KEYWORDS- Anilines
- acetylation
- acetanilide
- ethanoic anhydride
- Baker yeast
- bio-catalyst
