JOURNAL 3564
Organic Communications
VOLUME & ISSUE
Available Online: August 25,2025
Available Online: August 25,2025
PAGES
p.1 - 13
p.1 - 13
DOI ADDRESS
http://doi.org/10.25135/acg.oc.193.2506.3564 (DOI number will be activated after the manuscript has been available in an issue.)
http://doi.org/10.25135/acg.oc.193.2506.3564 (DOI number will be activated after the manuscript has been available in an issue.)
STATISTICS
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GRAPHICAL ABSTRACT
ABSTRACT
A one-pot, ionic-liquid-mediated synthesis has been developed for novel thiazolidine-4-ones containing a pyrazole and thiazole hybrid. This was achieved using a three-component reaction of 2-amino-thiazole, pyrazole-3-aldehyde, and mercaptoacetic acid in [bmim][PF6]. The whole procedure is robust and straightforward. By employing this protocol, a series of novel thiazolidine-4-ones containing pyrazole and thiazole hybrids were prepared in good yield (56-88%) and their preliminary cyclooxygenase activities were also studied and reported. The compounds 3h and 3k show the top-tier selective index for cyclooxygenase enzyme, in comparable with celecoxib as a standard.
KEYWORDS- Ionic liquid
- thiazoline-4-one
- COX-1/COX-2
- molecular docking
