Rare 1,2’-binaphthyls Produced by Nodulisporium hinnuleum Smith (ATCC 36102)

 In the course of processing extracts from fermentations with Nodulisporium hinnuleum Smith (ATCC 36102) to obtain demethoxyvirdin, we noticed that this fungus produced several other secondary metabolites as well. In an effort to identify these components, four new, related natural products designated hinnulin A-D (1-4) were isolated and characterized. Structure elucidation of the hinnulins, primarily by NMR spectroscopy, revealed that these belong to the rare class of 1,2’-binaphthyl natural products.