Cycloartane Glycosides from Astragalus erinaceus

One new cycloartane-type saponin, 3-O-[ β -D-xylopyranosyl-(1 → 2)- β -D-xylopyranosyl]-6-O- β -D-glucuronopyranosyl-3 β ,6 α ,16 β ,24(S),25- pentahydroxyxyxloartane (1) was isolated from the MeOH extract of whole plant parts of Astragalus erinaceus along with 5 known saponins (2-6), cyclodissectoside, cycloastragenol, 6-O- β -D-glucopyranosyl-3 β ,6 α ,16 β ,24(S),25-pentahydroxycycloartane, oleifolioside B and 3,6-di-O- β -D-xylopyranosyl-3 β ,6 α ,16 β ,24(S),25-pentahydroxycycloartane, respectively. Their structures were established by the extensive use of 1D- and 2D-NMR experiments along with ESIMS and HRMS analysis. The glucuronic acid moiety in cycloartanes is a very unusual finding.