JOURNAL 532


Records of Natural Products
VOLUME & ISSUE
Year: 2013 Issue: 1 January-March
PAGES
p.65 - 68
STATISTICS
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AUTHORS
    Michel F. Tala, Patricia D. Tchakam, Hippolyte K. Wabo, Ferdinand M. Talontsi, Pierre Tane, Jules R. Kuiate, Léon A. Tapondjou and Hartmut Laatsch
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


Betulinic acid (1), 5-hydroxy-3-methoxyxanthone (2), 1,6-dihydroxy-7-methoxyxanthone (3), daucosterol (4), bijaponicaxanthone C (5), hypercalin C (6), 1-hydroxy-6,7-dimethoxyxanthone (7), cadensin D (8) and 5-hydroxy-1,3-dimethoxyxanthone (9) were isolated from the roots of Hypericum riparium. These compounds are reported for the first time from this plant. The extracts and two of the isolated compounds (2 and 8) exhibited both antibacterial and antifungal activities that varied between the microbial species (MIC = 0.97-250 µg/mL). In addition, the brine-shrimp (Artemia salina) lethality bioassay of compound 6 showed potent cytotoxicity with LD 50 of 3.23 µg/mL.

KEYWORDS
  • Hypericum riparium
  • antibacterial
  • antifungal
  • cytotoxic.

SUPPORTING INFORMATION


Supporting Information
Download File 10- RNP-1206-82-SI.pdf (1.5 MB)