JOURNAL 666


Records of Natural Products
VOLUME & ISSUE
Year: 2013 Issue: 3 July-September
PAGES
p.210 - 219
STATISTICS
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AUTHORS
    Ozlem Demirkiran, M. Ahmad Mesaik, Hayrettin Beynek, Ahmed Abbaskhan and M. Iqbal Choudhary
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


 The MeOH extract of aerial parts of H. monbretii Spach. have yielded quercetin (1), kaempferol (2), quercitrin (3), hyperin (4), myricitrin (5), rutin (6), I 3 II 8′′ biapigenin (7), methyl chlorogenate (8), 5-O-p-coumaroylquinic acid (9), and chlorogenic acid (5-O-caffeoyl quinic acid) (10), mangiferin (11), and shikimic acid (12). Three compounds 1, 2 and 4 were found to have an immunomodulating inhibitory activity on the oxidative burst response of human neutrophils, as well on mouse peritoneal macrophages. E ffects of compounds on whole blood phagocytes activity was found to be with IC 50 ranging between 8.0-12.2 µg/mL. O nly compounds 1, and 2 were found to interfere with T-cell proliferation, and IL-2 release in PHA activated peripheral blood mononuclear cells system. To the best of our knowledge, this is the first report of phytochemical and biological activity study on H. montbretii Spach.

KEYWORDS
  • Hypericum monbretii Spach.
  • phenolics
  • immunomodulating inhibitory activity
  • reactive oxygen species
  • T-cell proliferation
  • IL-2 production.

SUPPORTING INFORMATION


Supporting Information
Download File 32-RNP-1212-220-supporting.pdf (18.71 KB)