JOURNAL 667


Records of Natural Products
VOLUME & ISSUE
Year: 2013 Issue: 3 July-September
PAGES
p.220 - 224
STATISTICS
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AUTHORS
    Zhi Na, Qishi Song and Hua b in Hu
PDF OF ARTICLE

GRAPHICAL ABSTRACT


ABSTRACT


 A new prenylated xanthone, 1,6-dihydroxy-3,7-dimethoxy-2-(3,7-dimethyloct-2,6-dienyl) xanthone (3-O-methylcowaxanthone) (1), together with four known xanthones, cowaxanthone (2), 7-O-methylgarcinone (3), α-mangostin (4) and γ-mangostin (5) were isolated from the latex of Garcinia cowa. The structure of compound 1 was elucidated on the basis of spectroscopic data interpretation, including 1D and 2D NMR and HREIMS. The cytotoxic activitiy of 1against five human cancer cell lines, HL-60, SMMC-7721, A-549, MCF-7 and SW480, was evaluated, but it was inactive (IC 50>40μM).

KEYWORDS
  • Garcinia cowa Roxb .
  • Guttifer ae
  • prenylated xanthone
  • 3-O-methylcowaxanthone .

SUPPORTING INFORMATION


Supporting Information
Download File 33-RNP-1301-239-supporting.pdf (569.14 KB)