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Sapwood of Carob Tree (Ceratonia siliqua L.) as a Potential Source of Bioactive Compounds

Short Report

JOURNAL 668

Records of Natural Products
VOLUME & ISSUE
Year: 2013 Issue: 3 July-September
PAGES
p.225 - 229
STATISTICS
Viewed 2329 times.
AUTHORS
    Luísa Custódio, Ana Luísa Escapa, João Patarra, Rosa Aligué, Fernando Alberício, Nuno Rosa Neng, José Manuel Florêncio Nogueira and Anabela Romano
PDF OF ARTICLE

GRAPHICAL ABSTRACT

ABSTRACT

Methanol (ME) and hot water extracts (WE) of carob tree sapwood (Ceratonia siliqua L.) exhibited high antioxidant activity and were rich in phenolic compounds, with the main compounds identified by HPLC/DAD as gentisic acid and (-)-epicatechin. The ME displayed a high in vitro antitumor activity against human tumoural cell lines and reduced intracellular ROS production by HeLa cells after treatment with H 2O 2.
(-)-Epicatechin was shown to contribute to the cytotoxic activity of the ME. This is the first report on the biological activity of carob tree sapwood.

 KEYWORDS
  • Antioxidant activity
  • cytotoxic
  • gentisic acid
  • phenolic compounds
  • ROS.

SUPPORTING INFORMATION

Supporting Information
Download File 34-RNP-1110-806-supporting.pdf (55.93 KB)