New Oxoprotoberberine and Aporphine Alkaloids from the Roots of Amoora cucullata with Their Antiproliferative Activites

Original Article

JOURNAL 1181

Records of Natural Products

VOLUME & ISSUE

Year: 2019 Issue: 6 November-December

PAGES

p.491 - 498

DOI ADDRESS

http://doi.org/10.25135/rnp.128.19.02.1181

STATISTICS

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AUTHORS

Parinuch Chumkaew
Passakorn Teerapongpisan
Jaraslak Pechwang
Theera Srisawat

GRAPHICAL ABSTRACT

ABSTRACT

Two new oxoprotoberberine alkaloids, amocurine A and B (1 and 2), a new aporphine alkaloid, amocurine C (3), along with three known compounds (4-6) were isolated from the roots of Amoora cucullata. Their structures were determined by analysis of spectroscopic data. The isolated compounds were evaluated for their antiproliferative activity against three human cancer cell lines (KB, oral cavity; MCF-7, breast cancer; and NCI-H187, small cell lung cancer). Compounds 3 showed the most potent activities against KB and MCF-7 cell lines with IC50 values 3.5 and 4.2 mM, respectively.

KEYWORDS

Oxoprotoberberine
Aporphine
Antiproliferative activity
Amoora cucullata

SUPPORTING INFORMATION

Supporting Information

Download File A8-128-RNP-1902-1181-SI.pdf (263.69 KB)